Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 8/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.58 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.52 |
| ▸ | CNR2 | P34972 | 2/20 | 0.52 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.51 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.51 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.51 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.51 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.51 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963668 | 1.00 | PLA2G2A (0.78) | PLA2G2AKDM4EHSD17B10PTGS2PLA2G1B | |
| SCHEMBL7962129 | 1.00 | PLA2G2A (0.78) | PLA2G2AKDM4EHSD17B10PTGS2PLA2G1B | |
| SCHEMBL7962226 | 1.00 | PLA2G2A (0.78) | PLA2G2AKDM4EHSD17B10PTGS2PLA2G1B | |
| SCHEMBL8300469 | 0.92 | PLA2G2A (0.80) | PLA2G2AKDM4EHSD17B10PTGS2PLA2G1B | |
| SCHEMBL9371452 | 0.89 | PLA2G2A (0.82) | PLA2G2AKDM4EHSD17B10PTGS2PLA2G1B | |
| SCHEMBL7952654 | 0.89 | PLA2G2A (0.82) | PLA2G2AKDM4EHSD17B10PTGS2PLA2G1B | |
| SCHEMBL7961727 | 0.88 | PLA2G2A (1.00) | PLA2G2AKDM4EHSD17B10 | |
| SCHEMBL7964650 | 0.88 | PLA2G2A (1.00) | PLA2G2AKDM4EHSD17B10 | |
| SCHEMBL7963463 | 0.88 | PLA2G2A (1.00) | PLA2G2AKDM4EHSD17B10 | |
| SCHEMBL7953737 | 0.88 | PLA2G2A (1.00) | PLA2G2AKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6252084-B1 | THERAPY FOR SEPSIS SHOCK | ELI LILLY AND COMPANY | 2001-06-26 | — | — | US | disclosed |
| EP-0620215-B1 | 1H-indole-3-acetamide derivatives as sPLA2 inhibitors | LILLY CO ELI (US) | 1999-08-18 | — | — | EP | disclosed |
| US-5684034-A | INHIBITORS OF HUMAN NON-PANCREATIC SECRETORY PHOSPHOLIPASE A2, TREATMENT OF SEPTIC SHOCK, TRAUMA, RESPIRATORY DISORDERS, RHEUMATIC ARTHRITIS, INHIBITORS OF ARACHIDONIC ACID RELEASE | ELI LILLY AND COMPANY (US) | 1997-11-04 | — | — | US | disclosed |
| EP-0620215-A1 | 1H-indole-3-acetamide derivatives as sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 1994-10-19 | — | — | EP | disclosed |