Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.59 |
| ▸ | MC4R | P32245 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6731270 | 0.87 | SIGMAR1 (0.67) | SIGMAR1ALDH1A1TSHRNPC1LMNA | |
| SCHEMBL12727134 | 0.85 | KDM4E (0.68) | SIGMAR1ALDH1A1NPC1KDM4E | |
| SCHEMBL21034452 | 0.85 | SIGMAR1 (0.64) | SIGMAR1ALDH1A1TSHRNPC1LMNA | |
| SCHEMBL1029651 | 0.85 | RECQL (0.73) | SIGMAR1ALDH1A1TSHRNPC1LMNA | |
| SCHEMBL7131206 | 0.84 | KDM4E (0.78) | ALDH1A1TSHRLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL8188324 | 0.83 | SIGMAR1 (1.00) | SIGMAR1LMNAMC4R | |
| SCHEMBL576868 | 0.83 | SIGMAR1 (1.00) | SIGMAR1LMNAMC4R | |
| SCHEMBL2489199 | 0.83 | SIGMAR1 (1.00) | SIGMAR1LMNAMC4R | |
| SCHEMBL1415730 | 0.83 | SIGMAR1 (1.00) | SIGMAR1LMNAMC4R | |
| SCHEMBL1041303 | 0.83 | SIGMAR1 (1.00) | SIGMAR1LMNAMC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6200980-B1 | ADMINISTERING PHENYL PURINONE COMPOUND FOR TREATING PRECANCEROUS LEISONS | CELL PATHWAYS, INC. | 2001-03-13 | — | — | US | disclosed |
| EP-0526004-B1 | Pyrazolopyrimidinone antianginal agents | PFIZER LTD (GB) | 1997-10-08 | — | — | EP | disclosed |
| CN-1034503-C | Pyrazolopyrimidinone antianginal agents | PFIZER (US) | 1997-04-09 | — | — | CN | disclosed |
| US-5426107-A | Treatment of cardiovascular disorders, asthma, allergies | PFIZER INC. (US) | 1995-06-20 | — | — | US | disclosed |
| US-5272147-A | Pyrazolopyrimidinone antianginal agents | PFIZER INC. (US) | 1993-12-21 | — | — | US | disclosed |
| EP-0526004-A1 | Pyrazolopyrimidinone antianginal agents | Pfizer Limited (GB) | 1993-02-03 | — | — | EP | disclosed |
| CN-1068329-A | Pyrazolopyrimidinoneantianginal antianginal agents | PFIZER (US) | 1993-01-27 | — | — | CN | disclosed |