Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 13/20 | 0.35 |
| ▸ | RARB | P10826 | 12/20 | 0.35 |
| ▸ | RARG | P13631 | 11/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6552458 | 0.90 | RARA (0.33) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL7773711 | 0.81 | RARA (0.35) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL6292648 | 0.77 | RARA (0.43) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL6297202 | 0.77 | RARB (0.51) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL6595814 | 0.74 | RARA (0.38) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL6552904 | 0.71 | RARA (0.33) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL6088924 | 0.70 | RARB (0.34) | RARARARBRARG | |
| SCHEMBL6087866 | 0.70 | PDE4B (0.36) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL6552888 | 0.70 | RARA (0.34) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL6292560 | 0.68 | RARA (0.68) | RARARARBRARGRXRANR2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001070662-A2 | 2,4-PENTADIENOIC ACID DERIVATIVES HAVING SELECTIVE ACTIVITY FOR RETINOID X (RXR) RECEPTORS | ALLERGAN , INC. (US) | 2001-09-27 | — | — | WO | disclosed |