Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pradofloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.74 |
| ▸ | HPGD | P15428 | 6/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | CLK2 | P49760 | 1/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | TOP2A | P11388 | 4/20 | 0.43 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pradofloxacin SCHEMBL30595280 | 1.00 | ALDH1A1 (0.74) | ALDH1A1KDM4EHPGDHSD17B10MEN1 | |
| Pradofloxacin SCHEMBL150884 | 0.99 | ALDH1A1 (0.73) | ALDH1A1KDM4EHPGDHSD17B10MEN1 | |
| Pradofloxacin SCHEMBL7678035 | 0.99 | ALDH1A1 (0.73) | ALDH1A1KDM4EHPGDHSD17B10MEN1 | |
| Pradofloxacin SCHEMBL7488977 | 0.99 | ALDH1A1 (0.73) | ALDH1A1KDM4EHPGDHSD17B10MEN1 | |
| Pradofloxacin SCHEMBL2201509 | 0.99 | ALDH1A1 (0.73) | ALDH1A1KDM4EHPGDHSD17B10MEN1 | |
| Pradofloxacin SCHEMBL7962442 | 0.95 | ALDH1A1 (0.68) | ALDH1A1KDM4EHPGDHSD17B10MEN1 | |
| Pradofloxacin SCHEMBL7976296 | 0.95 | KDM4E (0.69) | ALDH1A1KDM4EHPGDHSD17B10MEN1 | |
| SCHEMBL9181426 | 0.91 | ALDH1A1 (0.73) | ALDH1A1KDM4EHPGDHSD17B10MEN1 | |
| SCHEMBL7962516 | 0.90 | KDM4E (0.67) | ALDH1A1KDM4EHPGDHSD17B10MEN1 | |
| Hydrochloric Acid SCHEMBL7546889 | 0.90 | KDM4E (0.62) | ALDH1A1KDM4EHPGDHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6323213-B1 | ANTIBIOTICS, BACTERICIDES FOR VETERINARY MEDICINE | BAYER AKTIENGESELLSCHAFT (DE) | 2001-11-27 | — | — | US | disclosed |
| US-6278013-B1 | AS CHEMICAL INTERMEDIATES FOR PREPARING QUINOLINECARBOXYLIC ACID DERIVATIVE ANTIBIOTICS USED IN VETERINARY MEDICINE | BAYER AKTIENGESELLSCHAFT (DE) | 2001-08-21 | — | — | US | disclosed |