SCHEMBL7962862

SCHEMBL7962862

O=C(C=Cc1ccc2ccccc2c1)NCCCCN1CCc2cc(OC(F)(F)F)ccc2C1

nearest known ligand 0.77

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 19/20 0.77
DRD3 P35462 19/20 0.77
HTR1D P28221 1/20 0.53
HTR1B P28222 1/20 0.53
HDAC3 O15379 1/20 0.47
HDAC4 P56524 1/20 0.47
HDAC1 Q13547 1/20 0.47
HDAC7 Q8WUI4 1/20 0.47
HDAC2 Q92769 1/20 0.47
HDAC10 Q969S8 1/20 0.47
HDAC11 Q96DB2 1/20 0.47
HDAC8 Q9BY41 1/20 0.47
HDAC6 Q9UBN7 1/20 0.47
HDAC9 Q9UKV0 1/20 0.47
HDAC5 Q9UQL6 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7962861 1.00 DRD2 (0.77) DRD2DRD3HTR1DHTR1BHDAC3
SCHEMBL7853775 0.97 DRD2 (0.82) DRD2DRD3HTR1DHTR1B
SCHEMBL7854513 0.97 DRD2 (0.82) DRD2DRD3HTR1DHTR1B
SCHEMBL7976527 0.88 DRD2 (0.79) DRD2DRD3HTR1DHTR1BHDAC3
SCHEMBL7976525 0.88 DRD2 (0.79) DRD2DRD3HTR1DHTR1BHDAC3
SCHEMBL7854789 0.87 DRD2 (1.00) DRD2DRD3HTR1DHTR1B
SCHEMBL7850964 0.86 DRD2 (0.78) DRD2DRD3HDAC3HDAC1HDAC6
SCHEMBL7854682 0.86 DRD2 (0.78) DRD2DRD3HDAC3HDAC1HDAC6
SCHEMBL7979204 0.85 DRD2 (0.68) DRD2DRD3HDAC3HDAC4HDAC1
SCHEMBL7979208 0.85 DRD2 (0.68) DRD2DRD3HDAC3HDAC4HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6274593-B1 TREATING PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA, AND PARKINSON*S DISEASE SMITHKLINE BEECHAM P.L.C. (GB) 2001-08-14 US claimed
EP-0980357-A1 SUBSTITUTED TETRAHYDRO ISOQUINOLINES AS MODULATORS OF DOPAMINE D3 RECEPTORS SMITHKLINE BEECHAM PLC (GB) 2000-02-23 EP claimed
WO-1998050363-A1 SUBSTITUTED TETRAHYDRO ISOQUINOLINES AS MODULATORS OF DOPAMINE D3 RECEPTORS SMITHKLINE BEECHAM PLC (GB) 1998-11-12 WO claimed
US-6274593-B1 TREATING PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA, AND PARKINSON*S DISEASE SMITHKLINE BEECHAM P.L.C. (GB) 2001-08-14 US disclosed
EP-0980357-A1 SUBSTITUTED TETRAHYDRO ISOQUINOLINES AS MODULATORS OF DOPAMINE D3 RECEPTORS SMITHKLINE BEECHAM PLC (GB) 2000-02-23 EP disclosed
WO-1998050363-A1 SUBSTITUTED TETRAHYDRO ISOQUINOLINES AS MODULATORS OF DOPAMINE D3 RECEPTORS SMITHKLINE BEECHAM PLC (GB) 1998-11-12 WO disclosed