Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 18/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | PDE2A | O00408 | 1/20 | 0.57 |
| ▸ | PDE6D | O43924 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | PDE9A | O76083 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | PDE6A | P16499 | 1/20 | 0.57 |
| ▸ | PDE6G | P18545 | 1/20 | 0.57 |
| ▸ | PDE4A | P27815 | 1/20 | 0.57 |
| ▸ | PDE6B | P35913 | 1/20 | 0.57 |
| ▸ | PDE6C | P51160 | 1/20 | 0.57 |
| ▸ | PDE1A | P54750 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7950714 | 0.87 | PDE5A (0.52) | PDE5AKDM4EKMT2AMEN1MAPT | |
| SCHEMBL7029661 | 0.85 | PDE5A (0.62) | PDE5AKDM4EKMT2AMEN1MAPT | |
| SCHEMBL7950444 | 0.85 | KDM4E (0.45) | PDE5AKDM4EKMT2AMEN1MAPT | |
| SCHEMBL7965371 | 0.84 | PDE5A (0.52) | PDE5AKDM4EKMT2AMEN1MAPT | |
| SCHEMBL7965285 | 0.84 | KDM4E (0.57) | PDE5AKDM4EKMT2AMEN1MAPT | |
| SCHEMBL7960704 | 0.84 | PDE5A (0.44) | PDE5AKDM4EKMT2AMEN1MAPT | |
| SCHEMBL7959312 | 0.84 | PDE5A (0.51) | PDE5AKDM4EKMT2AMEN1MAPT | |
| SCHEMBL7958810 | 0.83 | KDM4E (0.53) | PDE5AKDM4EKMT2AMEN1MAPT | |
| Sulfuric Acid SCHEMBL7718120 | 0.81 | PDE5A (0.56) | PDE5AKDM4EKMT2AMEN1MAPT | |
| SCHEMBL7959294 | 0.80 | PDE5A (0.56) | PDE5AKDM4EKMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6200980-B1 | ADMINISTERING PHENYL PURINONE COMPOUND FOR TREATING PRECANCEROUS LEISONS | CELL PATHWAYS, INC. | 2001-03-13 | — | — | US | disclosed |
| EP-0349239-B1 | Condensed pyrimidine derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | SMITH KLINE FRENCH LAB (GB) | 1994-03-16 | — | — | EP | disclosed |
| US-5075310-A | PYRIMIDONE DERIVATIVES AS BRONCHODILATORS | SMITH KLINE & FRENCH LABORATORIES, LTD. (GB) | 1991-12-24 | — | — | US | disclosed |
| EP-0349239-A2 | Condensed pyrimidine derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-01-03 | — | — | EP | disclosed |