Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | CASP6 | P55212 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | MGMT | P16455 | 3/20 | 0.52 |
| ▸ | CDK1 | P06493 | 3/20 | 0.52 |
| ▸ | CDK2 | P24941 | 3/20 | 0.52 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.52 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.52 |
| ▸ | PDE5A | O76074 | 4/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | GUSB | P08236 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7962891 | 0.84 | PDE5A (0.57) | KDM4EMEN1MAPTCASP6KMT2A | |
| SCHEMBL7958810 | 0.83 | KDM4E (0.53) | KDM4EMEN1MAPTCASP6KMT2A | |
| SCHEMBL11628099 | 0.74 | PDE5A (0.46) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4142417 | 0.74 | HTT (0.50) | MEN1KMT2APDE5APDE4APDE4B | |
| SCHEMBL11629646 | 0.73 | IDO1 (0.47) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7950714 | 0.71 | PDE5A (0.52) | KDM4EMEN1MAPTCASP6KMT2A | |
| SCHEMBL29362917 | 0.70 | KDM4E (0.46) | KDM4EMEN1MAPTCASP6KMT2A | |
| SCHEMBL22264907 | 0.70 | KDM4E (0.46) | KDM4EMEN1MAPTCASP6KMT2A | |
| SCHEMBL7950444 | 0.70 | KDM4E (0.45) | KDM4EMEN1MAPTCASP6KMT2A | |
| SCHEMBL30835050 | 0.70 | PDE5A (0.70) | KDM4EMAPTCDK1CDK2PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6200980-B1 | ADMINISTERING PHENYL PURINONE COMPOUND FOR TREATING PRECANCEROUS LEISONS | CELL PATHWAYS, INC. | 2001-03-13 | — | — | US | disclosed |
| EP-0352960-B1 | Purine compounds, process for their preparation and pharmaceutical compositions | SMITH KLINE FRENCH LAB (GB) | 1994-10-26 | — | — | EP | disclosed |
| US-5073559-A | 2-Substituted purinone having phosphodiesterase inhibitory activity | SMITH KLINE & FRENCH LABORATORIES, LTD. (GB) | 1991-12-17 | — | — | US | disclosed |
| EP-0352960-A2 | Purine compounds, process for their preparation and pharmaceutical compositions | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-01-31 | — | — | EP | disclosed |