Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 5/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.59 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.43 |
| ▸ | TYK2 | P29597 | 9/20 | 0.42 |
| ▸ | IL1B | P01584 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7962977 | 1.00 | PDE4A (0.59) | PDE4AKCNH2PDE4BPDE4CPDE4D | |
| SCHEMBL7960506 | 0.90 | PDE4A (0.66) | PDE4AKCNH2PDE4BPDE4CPDE4D | |
| SCHEMBL7961898 | 0.88 | PDE4A (0.64) | PDE4AKCNH2PDE4BPDE4CPDE4D | |
| SCHEMBL7963725 | 0.88 | PDE4A (0.64) | PDE4AKCNH2PDE4BPDE4CPDE4D | |
| SCHEMBL7960386 | 0.87 | PDE4A (0.63) | PDE4AKCNH2PDE4BPDE4CPDE4D | |
| SCHEMBL7954732 | 0.86 | PDE4A (0.62) | PDE4AKCNH2PDE4BPDE4CPDE4D | |
| SCHEMBL7960372 | 0.86 | PDE4A (0.62) | PDE4AKCNH2PDE4BPDE4CPDE4D | |
| SCHEMBL7951793 | 0.86 | PDE4A (0.62) | PDE4AKCNH2PDE4BPDE4CPDE4D | |
| SCHEMBL7963094 | 0.86 | PDE4A (0.62) | PDE4AKCNH2PDE4BPDE4CPDE4D | |
| SCHEMBL7951778 | 0.85 | PDE4A (0.61) | PDE4AKCNH2PDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331548-B1 | PREVENTION OR TREATMENT OF CYTOKINE RELATED DISEASES | SUNTORY LIMITED (JP) | 2001-12-18 | — | — | US | disclosed |
| EP-0978516-A1 | 1-CYCLOALKYL-1,8-NAPHTHYRIDIN-4-ONE DERIVATIVES WITH PHOSPHODIESTERASE IV INHIBITORY ACTIVITY | SUNTORY LIMITED (JP) | 2000-02-09 | — | — | EP | disclosed |