Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 8/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 8/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | BCR | P11274 | 1/20 | 0.33 |
| ▸ | CFTR | P13569 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8327305 | 0.90 | MKNK1 (0.36) | MKNK1MKNK2P2RX7CYP11B2EGFR | |
| SCHEMBL7967982 | 0.89 | CYP11B2 (0.37) | MKNK1MKNK2P2RX7CYP11B2EGFR | |
| SCHEMBL7965769 | 0.87 | CFTR (0.41) | CYP11B2CFTR | |
| SCHEMBL7965530 | 0.84 | MKNK1 (0.40) | MKNK1MKNK2CSNK1DCSNK1ECYP11B2 | |
| SCHEMBL2158254 | 0.84 | MKNK1 (0.43) | MKNK1MKNK2CSNK1DCSNK1EP2RX7 | |
| SCHEMBL7965727 | 0.82 | MKNK1 (0.38) | MKNK1MKNK2CSNK1DCSNK1ESCN9A | |
| SCHEMBL7962850 | 0.81 | MKNK1 (0.41) | MKNK1MKNK2CSNK1DCSNK1ECYP11B2 | |
| SCHEMBL7953686 | 0.79 | POLB (0.31) | — | |
| SCHEMBL7962090 | 0.79 | CYP11B2 (0.39) | CYP11B2 | |
| SCHEMBL7955168 | 0.77 | CSNK1D (0.39) | MKNK1MKNK2CSNK1DCSNK1EP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | claimed |
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | disclosed |