Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 17/20 | 0.48 |
| ▸ | CCND1 | P24385 | 17/20 | 0.48 |
| ▸ | CCNE2 | O96020 | 11/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 11/20 | 0.48 |
| ▸ | CDK2 | P24941 | 11/20 | 0.48 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.47 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.39 |
| ▸ | CDK1 | P06493 | 2/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7961637 | 0.90 | CDK4 (0.52) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7963257 | 0.88 | CDK4 (0.53) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7965973 | 0.87 | CDK4 (0.49) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7961465 | 0.86 | CRHR1 (0.48) | CDK4CCND1CCNE2CCNE1CDK2 | |
| Acetic Acid SCHEMBL8113498 | 0.85 | CDK4 (0.52) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL8123969 | 0.84 | CDK4 (0.53) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7963032 | 0.82 | CDK4 (0.51) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7965698 | 0.82 | CDK4 (0.47) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7967869 | 0.79 | CDK4 (0.48) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7963176 | 0.78 | CRHR1 (0.46) | CDK4CCND1CCNE2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218397-B1 | FOR THERAPY OF STRESS-RELATED ILLNESSES, SUCH AS STRESS-INDUCED DEPRESSION, ANXIETY, AND HEADACHE; ABDOMINAL BOWEL SYNDROME; INFLAMMATORY DISEASES; IMMUNE SUPPRESSION; ALZHEIMER'S DISEASE; GASTRONINTESTINAL DISEASES | PFIZER INC | 2001-04-17 | — | — | US | disclosed |