Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | MEN1 | O00255 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | HPGD | P15428 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | PKM | P14618 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | ALPG | P10696 | 1/20 | 0.50 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 5/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963571 | 1.00 | EGFR (0.53) | EGFRERBB2KDM4EMEN1ALDH1A1 | |
| SCHEMBL7963565 | 1.00 | EGFR (0.53) | EGFRERBB2KDM4EMEN1ALDH1A1 | |
| SCHEMBL8321144 | 0.86 | KMT2A (0.45) | EGFRERBB2KDM4EMEN1ALDH1A1 | |
| SCHEMBL7952691 | 0.85 | EGFR (0.55) | EGFRERBB2KDM4EMEN1ALDH1A1 | |
| SCHEMBL7952695 | 0.85 | EGFR (0.55) | EGFRERBB2KDM4EMEN1ALDH1A1 | |
| SCHEMBL7952698 | 0.85 | EGFR (0.55) | EGFRERBB2KDM4EMEN1ALDH1A1 | |
| SCHEMBL7963391 | 0.84 | LMNA (0.38) | EGFRERBB2POLBGAAMAPT | |
| SCHEMBL7963384 | 0.84 | LMNA (0.38) | EGFRERBB2POLBGAAMAPT | |
| SCHEMBL7963389 | 0.84 | LMNA (0.38) | EGFRERBB2POLBGAAMAPT | |
| SCHEMBL4185081 | 0.83 | EGFR (0.56) | EGFRERBB2KDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996040629-A1 | TYRPHOSTIN-LIKE COMPOUNDS FOR THE TREATMENT OF CELL PROLIFERATIVE DISORDERS OR CELL DIFFERENTIATION DISORDERS | SUGEN, INC. (US) | 1996-12-19 | — | — | WO | claimed |
| US-6225346-B1 | FOR THERAPY AND PROPHYLAXIS OF CELL PROLIFERATIVE DISORDERS OR CELL DIFFERENTIATION DISORDERS ASSOCIATED WITH PARTICULAR TYROSINE KINASES BY INHIBITING ONE OR MORE ABNORMAL TYROSINE KINASE ACTIVITIES | SUGEN, INC. | 2001-05-01 | — | — | US | disclosed |
| WO-1996040629-A1 | TYRPHOSTIN-LIKE COMPOUNDS FOR THE TREATMENT OF CELL PROLIFERATIVE DISORDERS OR CELL DIFFERENTIATION DISORDERS | SUGEN, INC. (US) | 1996-12-19 | — | — | WO | disclosed |