Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 18/20 | 0.53 |
| ▸ | JAK3 | P52333 | 9/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 8/20 | 0.52 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7975073 | 0.92 | JAK2 (0.53) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL13486894 | 0.89 | JAK2 (0.53) | JAK2JAK3PTK2JAK1EGLN2 | |
| SCHEMBL2144914 | 0.89 | JAK2 (0.56) | JAK2JAK3PTK2JAK1EGLN2 | |
| SCHEMBL7977784 | 0.88 | JAK2 (0.60) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL3214565 | 0.88 | JAK2 (0.60) | JAK2JAK3PTK2EGLN2 | |
| SCHEMBL3203477 | 0.87 | JAK2 (0.53) | JAK2JAK3PTK2JAK1EGLN2 | |
| SCHEMBL3204783 | 0.86 | JAK2 (0.53) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL13276297 | 0.85 | JAK2 (0.66) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL3200315 | 0.85 | JAK2 (0.66) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL16248911 | 0.84 | JAK2 (0.56) | JAK2JAK3PTK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010188-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES. | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |