Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 17/20 | 0.60 |
| ▸ | JAK3 | P52333 | 11/20 | 0.60 |
| ▸ | PTK2 | Q05397 | 11/20 | 0.60 |
| ▸ | JAK1 | P23458 | 2/20 | 0.54 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7975073 | 0.89 | JAK2 (0.53) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL2145331 | 0.88 | JAK2 (0.60) | JAK2JAK3PTK2JAK1TYK2 | |
| SCHEMBL2144504 | 0.88 | JAK2 (0.60) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL7963634 | 0.88 | JAK2 (0.53) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL3213810 | 0.84 | JAK2 (0.74) | JAK2JAK3PTK2JAK1TYK2 | |
| SCHEMBL7974924 | 0.84 | JAK2 (0.74) | JAK2JAK3PTK2JAK1TYK2 | |
| SCHEMBL13072782 | 0.84 | JAK2 (0.74) | JAK2JAK3PTK2JAK1TYK2 | |
| SCHEMBL3212126 | 0.81 | JAK2 (0.60) | JAK2JAK3PTK2JAK1TYK2 | |
| SCHEMBL3204351 | 0.80 | JAK2 (0.78) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL3215113 | 0.80 | JAK2 (0.78) | JAK2JAK3PTK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010188-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES. | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |