Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 1/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.59 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.59 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.59 |
| ▸ | INSR | P06213 | 1/20 | 0.59 |
| ▸ | ROS1 | P08922 | 1/20 | 0.59 |
| ▸ | PIM1 | P11309 | 1/20 | 0.59 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.59 |
| ▸ | PRKACA | P17612 | 1/20 | 0.59 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.59 |
| ▸ | AKT1 | P31749 | 1/20 | 0.59 |
| ▸ | FLT3 | P36888 | 1/20 | 0.59 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.59 |
| ▸ | CLK2 | P49760 | 1/20 | 0.59 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.59 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.59 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.59 |
| ▸ | STK3 | Q13188 | 1/20 | 0.59 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.59 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8358226 | 0.80 | SRC (0.49) | RIPK2ALDH1A1HSD17B10POLBMAPT | |
| SCHEMBL7965381 | 0.69 | CDK4 (0.41) | CSNK1DRIPK2ALDH1A1HSD17B10MAPT | |
| SCHEMBL4524097 | 0.69 | PLK4 (0.54) | PLK4ROCK2RPS6KA5MAP4K4INSR | |
| SCHEMBL7967691 | 0.69 | PLK4 (0.54) | PLK4ROCK2RPS6KA5MAP4K4INSR | |
| SCHEMBL8355989 | 0.66 | SRC (0.53) | PLK4ROCK2RPS6KA5MAP4K4INSR | |
| SCHEMBL3391811 | 0.63 | NPC1 (0.47) | PIM1ALDH1A1HSD17B10POLBMAPT | |
| SCHEMBL11478440 | 0.62 | SMN1; SMN2 (0.56) | ALDH1A1HSD17B10POLBMAPTHPGD | |
| SCHEMBL22293534 | 0.62 | PLK4 (0.42) | PLK4ROCK2RPS6KA5MAP4K4INSR | |
| SCHEMBL27875388 | 0.62 | PARP1 (0.44) | RPS6KB1AURKBALDH1A1HSD17B10POLB | |
| Hydrochloric Acid SCHEMBL11471926 | 0.61 | SMN1; SMN2 (0.55) | ALDH1A1HSD17B10POLBMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218397-B1 | FOR THERAPY OF STRESS-RELATED ILLNESSES, SUCH AS STRESS-INDUCED DEPRESSION, ANXIETY, AND HEADACHE; ABDOMINAL BOWEL SYNDROME; INFLAMMATORY DISEASES; IMMUNE SUPPRESSION; ALZHEIMER'S DISEASE; GASTRONINTESTINAL DISEASES | PFIZER INC | 2001-04-17 | — | — | US | disclosed |
| EP-0674642-B1 | PYRAZOLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1994013677-A1 | PYRAZOLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER INC. (US) | 1994-06-23 | — | — | WO | disclosed |