Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 8/20 | 0.41 |
| ▸ | CCND1 | P24385 | 8/20 | 0.41 |
| ▸ | PI4KA | P42356 | 1/20 | 0.38 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.38 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 4/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CSK | P41240 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7967714 | 0.75 | TP53 (0.44) | CDK4CCND1ALDH1A1HSD17B10TLR8 | |
| SCHEMBL7963663 | 0.69 | PLK4 (0.59) | ALDH1A1HSD17B10RAB9AMAPTHPGD | |
| SCHEMBL7961966 | 0.67 | CDK4 (0.59) | CDK4CCND1CDK2 | |
| SCHEMBL28985365 | 0.62 | SIGMAR1 (0.48) | ALDH1A1HSD17B10RAB9AMAPTHPGD | |
| SCHEMBL20028436 | 0.61 | MDM2 (0.55) | ALDH1A1HSD17B10RAB9AMAPTHPGD | |
| SCHEMBL13790291 | 0.61 | PI4KA (0.62) | PI4KAPI4K2BPI4K2API4KBALDH1A1 | |
| SCHEMBL859246 | 0.59 | NPC1 (0.50) | ALDH1A1HSD17B10MAPTHPGDSMN1; SMN2 | |
| SCHEMBL9394244 | 0.59 | NPC1 (0.50) | ALDH1A1HSD17B10TLR8RAB9AMAPT | |
| SCHEMBL5277301 | 0.59 | TDP1 (0.52) | ALDH1A1HSD17B10TLR8HPGDHTT | |
| SCHEMBL1354001 | 0.58 | NPC1 (0.39) | ALDH1A1HSD17B10MAPTHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218397-B1 | FOR THERAPY OF STRESS-RELATED ILLNESSES, SUCH AS STRESS-INDUCED DEPRESSION, ANXIETY, AND HEADACHE; ABDOMINAL BOWEL SYNDROME; INFLAMMATORY DISEASES; IMMUNE SUPPRESSION; ALZHEIMER'S DISEASE; GASTRONINTESTINAL DISEASES | PFIZER INC | 2001-04-17 | — | — | US | disclosed |
| EP-0674642-B1 | PYRAZOLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER (US) | 2000-08-23 | — | — | EP | disclosed |