Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 17/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.70 |
| ▸ | LMNA | P02545 | 3/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.70 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.70 |
| ▸ | MAPT | P10636 | 11/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.69 |
| ▸ | HPGD | P15428 | 3/20 | 0.69 |
| ▸ | HTT | P42858 | 2/20 | 0.69 |
| ▸ | ATM | Q13315 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | TP53 | P04637 | 4/20 | 0.64 |
| ▸ | BRAF | P15056 | 2/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | CASP1 | P29466 | 1/20 | 0.55 |
| ▸ | CASP7 | P55210 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | CDK9 | P50750 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2923400 | 0.83 | GAA (0.83) | GAAKDM4ELMNAMAPK1MAPT | |
| SCHEMBL31355246 | 0.82 | GAA (0.83) | GAAKDM4ELMNAMAPK1RXFP1 | |
| SCHEMBL2921992 | 0.82 | GAA (0.77) | GAAKDM4ELMNAMAPK1MAPT | |
| SCHEMBL14022531 | 0.82 | GAA (0.65) | GAAKDM4ELMNAMAPK1RXFP1 | |
| SCHEMBL6644876 | 0.82 | GAA (0.73) | GAAKDM4ELMNAMAPK1RXFP1 | |
| SCHEMBL31355312 | 0.81 | GAA (0.79) | GAAKDM4ELMNAMAPK1RXFP1 | |
| SCHEMBL14022528 | 0.80 | GAA (1.00) | GAAKDM4ELMNAMAPK1RXFP1 | |
| SCHEMBL2918905 | 0.79 | GAA (0.65) | GAAKDM4ELMNAMAPK1RXFP1 | |
| SCHEMBL12781599 | 0.78 | ADRA1B (0.71) | GAAKDM4ELMNAMAPK1MAPT | |
| SCHEMBL2924128 | 0.78 | GAA (0.78) | GAAKDM4ELMNAMAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001027119-A2 | SUBSTANCE LIBRARY CONTAINING BICYCLIC IMIDAZO-5-YL-AMINES AND/OR BICYCLIC IMIDAZO-3-YL-AMINES | Grünenthal GmbH (DE) | 2001-04-19 | — | — | WO | claimed |
| US-20250032485-A1 | APPLICATION OF IMIDAZO [1,2-A] PYRAZINE COMPOUNDS OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS IN THE PREPARATION OF ANTI-CORONAVIRUS DRUGS | UNIV GUANGZHOU MEDICAL (CN) | 2025-01-30 | — | — | US | disclosed |
| WO-2001027119-A2 | SUBSTANCE LIBRARY CONTAINING BICYCLIC IMIDAZO-5-YL-AMINES AND/OR BICYCLIC IMIDAZO-3-YL-AMINES | Grünenthal GmbH (DE) | 2001-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250032485-A1 | APPLICATION OF IMIDAZO [1,2-A] PYRAZINE COMPOUNDS OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS IN THE PREPARATION OF ANTI-CORONAVIRUS DRUGS | TOP1, TDP1, TOP2A | GAA 2008/4885KDM4E 2246/4885LMNA 1337/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.