Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | F2 | P00734 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4862778 | 0.77 | RECQL (0.48) | GAAALDH1A1RECQLCYP1A2CYP2C9 | |
| SCHEMBL22326350 | 0.74 | GAA (0.88) | GAAALDH1A1RECQLCYP1A2CYP2C9 | |
| SCHEMBL9544542 | 0.74 | GAA (0.58) | GAAALDH1A1RECQLCYP1A2CYP2C9 | |
| SCHEMBL15292529 | 0.73 | GAA (0.62) | GAAALDH1A1RECQLCYP1A2CYP2C9 | |
| SCHEMBL20673373 | 0.73 | GAA (0.57) | GAAALDH1A1RECQLCYP1A2CYP2C9 | |
| SCHEMBL5550792 | 0.72 | GAA (0.66) | GAAALDH1A1RECQLCYP1A2CYP2C9 | |
| SCHEMBL12767494 | 0.71 | GAA (0.51) | GAAALDH1A1RECQLCYP1A2CYP2C9 | |
| SCHEMBL4851745 | 0.71 | RECQL (0.55) | GAAALDH1A1RECQLCYP1A2CYP2C9 | |
| SCHEMBL6625137 | 0.71 | GAA (0.69) | GAAALDH1A1RECQLCYP1A2CYP2C9 | |
| SCHEMBL2570416 | 0.71 | GAA (0.59) | GAAALDH1A1RECQLCYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271357-B1 | REACTING SYNTHON WITH HYDRAZINE MOIETY WITH A SYNTHON HAVING ALDEHYDE MOIETY TO FORM COMPOUNDS THAT MIMIC OLIGONUCLEOTIDES | ISIS PHARMACEUTICALS, INC. | 2001-08-07 | — | — | US | disclosed |
| US-6121433-A | FOR DIAGNOSTIC, RESEARCH AND THERAPEUTIC USE; MIMIC OR MODULATE PROTEINS, ENZYMES, NUCLEIC ACIDS AND LIPIDS | ISIS PHARMACEUTICALS, INC. (US) | 2000-09-19 | — | — | US | disclosed |
| EP-0746326-A4 | OLIGOMERIC COMPOUNDS HAVING NITROGEN-CONTAINING LINKAGES | ISIS PHARMACEUTICALS INC (US) | 2000-06-14 | — | — | EP | disclosed |
| US-5783682-A | Oligonucleotide mimics having nitrogen-containing linkages | ISIS PHARMACEUTICALS, INC. (US) | 1998-07-21 | — | — | US | disclosed |
| EP-0746326-A1 | OLIGOMERIC COMPOUNDS HAVING NITROGEN-CONTAINING LINKAGES | ISIS PHARMACEUTICALS, INC. (US) | 1996-12-11 | — | — | EP | disclosed |
| WO-1995018623-A1 | OLIGOMERIC COMPOUNDS HAVING NITROGEN-CONTAINING LINKAGES | ISIS PHARMACEUTICALS, INC. (US) | 1995-07-13 | — | — | WO | disclosed |