SCHEMBL7963732

SCHEMBL7963732

C[SiH](C)Oc1cc2c(C(C)(C)C)cccc2[nH]1

nearest known ligand 0.45

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 5/20 0.45
CA2 P00918 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25574661 0.75 KIF11 (0.51) KIF11CA2
SCHEMBL24974318 0.73 KIF11 (0.53) KIF11CA2
SCHEMBL19286546 0.73 KIF11 (0.53) KIF11CA2
SCHEMBL21151024 0.69 KIF11 (0.49) KIF11CA2
SCHEMBL28800618 0.68 KIF11 (0.47) KIF11CA2
SCHEMBL5957884 0.67 KIF11 (0.39) KIF11
SCHEMBL9262946 0.67 KIF11 (0.39) KIF11
SCHEMBL10312976 0.66 KIF11 (0.62) KIF11
SCHEMBL15828555 0.65 KIF11 (0.51) KIF11CA2
SCHEMBL7962579 0.64 KIF11 (0.40) KIF11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6265581-B1 REACTING SPECIFIED EPOXIDE AND AMINE, REACTING PRODUCT WITH ACID TO FORM ACID ADDITION SALT ELI LILLY AND COMPANY 2001-07-24 US disclosed
US-6093735-A TREATMENT OF TYPE II DIABETES AND OBESITY ELI LILLY AND COMPANY (US) 2000-07-25 US disclosed
US-6075040-A OBESITY AND DIABETES ELI LILLY AND COMPANY (US) 2000-06-13 US disclosed
US-6060492-A SIDE EFFECT REDUCTION ELI LILLY AND COMPANY (US) 2000-05-09 US disclosed
US-5977154-A OBESITY, DIABETES ELI LILLY AND COMPANY (US) 1999-11-02 US disclosed
US-5939443-A ANTIDIABETIC AGENTS AND TREATMENT OF OBESITY ELI LILLY AND COMPANY (US) 1999-08-17 US disclosed
US-5840738-A Selective β-3 adrenergic agonists ELI LILLY AND COMPANY (US) 1998-11-24 US disclosed
US-5808080-A Selective β3 adrenergic agonists ELI LILLY AND COMPANY (US) 1998-09-15 US disclosed
US-5786356-A TREATING TYPE II DIABETES, OBESITY ELI LILLY AND COMPANY (US) 1998-07-28 US disclosed
WO-1997010825-A1 SELECTIVE β3 ADRENERGIC AGONISTS ELI LILLY AND COMPANY (US) 1997-03-27 WO disclosed
EP-0764640-A1 Selective beta3 adrenergic agonists ELI LILLY AND COMPANY (US) 1997-03-26 EP disclosed