Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 1/20 | 0.51 |
| ▸ | ACE | P12821 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 2/20 | 0.45 |
| ▸ | CTSL | P07711 | 2/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | CMA1 | P23946 | 5/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5711416 | 1.00 | PREP (0.51) | PREPACECTSKCTSLCTSB | |
| SCHEMBL5711375 | 0.83 | ACE (0.41) | PREPACECTSKCTSLCTSB | |
| SCHEMBL5711178 | 0.82 | ACE (0.56) | PREPACEMEN1KMT2A | |
| SCHEMBL6740347 | 0.81 | CMA1 (0.53) | PREPCTSKCTSLCTSBCMA1 | |
| SCHEMBL5711285 | 0.79 | CCR1 (0.50) | ACEELANE | |
| SCHEMBL8168155 | 0.79 | CMA1 (0.61) | ACECTSKCTSLCTSBCMA1 | |
| SCHEMBL17378396 | 0.79 | CMA1 (0.61) | ACECTSKCTSLCTSBCMA1 | |
| SCHEMBL4445986 | 0.79 | CMA1 (0.61) | ACECTSKCTSLCTSBCMA1 | |
| SCHEMBL2162326 | 0.79 | CMA1 (0.61) | ACECTSKCTSLCTSBCMA1 | |
| SCHEMBL6284248 | 0.79 | CMA1 (0.61) | ACECTSKCTSLCTSBCMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265381-B1 | MORPHOLINOUREA AND RELATED DERIVATIVES OF PENTAFLUOROETHYL PEPTIDES | MERRELL PHARMACEUTICALS, INC. | 2001-07-24 | — | — | US | disclosed |
| US-5714470-A | PENTAFLUORO ALKYL TERMINATED PEPTIDE DERIVATIVES; TREATMENT OF INFLAMMATORY DISEASES, EMPHYSEMA AND CHRONIC BRONCHITIS | MERRELL PHARMACEUTICALS, INC. (US) | 1998-02-03 | — | — | US | disclosed |