Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 4/20 | 0.47 |
| ▸ | CCND1 | P24385 | 4/20 | 0.47 |
| ▸ | CRHR1 | P34998 | 14/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | FPR3 | P25089 | 2/20 | 0.36 |
| ▸ | TSPO | P30536 | 2/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5601000 | 0.91 | CDK4 (0.53) | CDK4CCND1CRHR1TDP1 | |
| SCHEMBL8122461 | 0.86 | CDK4 (0.51) | CDK4CCND1CRHR1 | |
| SCHEMBL7965103 | 0.79 | CRHR1 (0.55) | CRHR1TDP1FPR3TSPOTMEM97 | |
| SCHEMBL7965430 | 0.74 | CDK4 (0.62) | CDK4CCND1CRHR1 | |
| SCHEMBL7952791 | 0.73 | CDK4 (0.47) | CDK4CCND1CRHR1 | |
| SCHEMBL6779487 | 0.71 | CRHR1 (0.56) | CRHR1TDP1 | |
| SCHEMBL7916255 | 0.69 | CRHR1 (0.54) | CRHR1TDP1FPR3TSPOTMEM97 | |
| SCHEMBL5707854 | 0.68 | CRHR1 (0.60) | CRHR1TDP1 | |
| SCHEMBL7446420 | 0.66 | CDK4 (0.49) | CDK4CCND1CRHR1 | |
| SCHEMBL8365944 | 0.66 | CRHR1 (0.60) | CRHR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218397-B1 | FOR THERAPY OF STRESS-RELATED ILLNESSES, SUCH AS STRESS-INDUCED DEPRESSION, ANXIETY, AND HEADACHE; ABDOMINAL BOWEL SYNDROME; INFLAMMATORY DISEASES; IMMUNE SUPPRESSION; ALZHEIMER'S DISEASE; GASTRONINTESTINAL DISEASES | PFIZER INC | 2001-04-17 | — | — | US | disclosed |
| EP-0674642-B1 | PYRAZOLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER (US) | 2000-08-23 | — | — | EP | disclosed |