Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | ACP3 | P15309 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7964271 | 1.00 | MAPT (0.42) | MAPTKDRSMN1; SMN2EGFRLMNA | |
| SCHEMBL7964269 | 1.00 | MAPT (0.42) | MAPTKDRSMN1; SMN2EGFRLMNA | |
| SCHEMBL7963389 | 0.87 | LMNA (0.38) | MAPTEGFRLMNAGAAHTR2A | |
| SCHEMBL7963384 | 0.87 | LMNA (0.38) | MAPTEGFRLMNAGAAHTR2A | |
| SCHEMBL7963391 | 0.87 | LMNA (0.38) | MAPTEGFRLMNAGAAHTR2A | |
| SCHEMBL7964110 | 0.85 | MAPT (0.43) | MAPTSMN1; SMN2EGFRLMNAGAA | |
| SCHEMBL7964107 | 0.85 | MAPT (0.43) | MAPTSMN1; SMN2EGFRLMNAGAA | |
| SCHEMBL7964113 | 0.85 | MAPT (0.43) | MAPTSMN1; SMN2EGFRLMNAGAA | |
| SCHEMBL7967179 | 0.82 | SMN1; SMN2 (0.44) | MAPTKDRSMN1; SMN2EGFRLMNA | |
| SCHEMBL7967176 | 0.82 | SMN1; SMN2 (0.44) | MAPTKDRSMN1; SMN2EGFRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996040629-A1 | TYRPHOSTIN-LIKE COMPOUNDS FOR THE TREATMENT OF CELL PROLIFERATIVE DISORDERS OR CELL DIFFERENTIATION DISORDERS | SUGEN, INC. (US) | 1996-12-19 | — | — | WO | claimed |
| US-6225346-B1 | FOR THERAPY AND PROPHYLAXIS OF CELL PROLIFERATIVE DISORDERS OR CELL DIFFERENTIATION DISORDERS ASSOCIATED WITH PARTICULAR TYROSINE KINASES BY INHIBITING ONE OR MORE ABNORMAL TYROSINE KINASE ACTIVITIES | SUGEN, INC. | 2001-05-01 | — | — | US | disclosed |