Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 2/20 | 0.46 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.46 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.46 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.41 |
| ▸ | GUSB | P08236 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALPI | P09923 | 1/20 | 0.38 |
| ▸ | ALPG | P10696 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7960263 | 0.85 | GRIA1 (0.50) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL7960858 | 0.83 | ALDH1A1 (0.48) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL7961923 | 0.82 | GRIA1 (0.46) | GRIA1GRIA2GRIA3GRIA4ALDH1A1 | |
| SCHEMBL7958054 | 0.81 | GRIA1 (0.56) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL7958315 | 0.81 | GRIA1 (0.47) | GRIA1GRIA2GRIA3GRIA4KDM4E | |
| SCHEMBL7949818 | 0.79 | GRIA1 (0.51) | GRIA1GRIA2GRIA3GRIA4KDM4E | |
| SCHEMBL7959292 | 0.77 | GRIA1 (0.53) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL7948153 | 0.77 | GRIA1 (0.61) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL7955952 | 0.77 | GRIA1 (0.53) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL7464140 | 0.77 | GRIA1 (0.55) | GRIA1GRIA2GRIA3GRIA4GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6172065-B1 | CENTRAL NERVOUS SYSTEM DISORDERS | WARNER-LAMBERT COMPANY | 2001-01-09 | — | — | US | claimed |
| WO-1998023599-A1 | UREA AND THIOUREA DERIVATIVES OF SUBSTITUTED QUINOXALINE 2,3-DIONES AS GLUTAMATE RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1998-06-04 | — | — | WO | claimed |
| US-6172065-B1 | CENTRAL NERVOUS SYSTEM DISORDERS | WARNER-LAMBERT COMPANY | 2001-01-09 | — | — | US | disclosed |
| WO-1998023599-A1 | UREA AND THIOUREA DERIVATIVES OF SUBSTITUTED QUINOXALINE 2,3-DIONES AS GLUTAMATE RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1998-06-04 | — | — | WO | disclosed |