Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 16/20 | 0.66 |
| ▸ | JAK3 | P52333 | 13/20 | 0.66 |
| ▸ | PTK2 | Q05397 | 12/20 | 0.66 |
| ▸ | JAK1 | P23458 | 2/20 | 0.54 |
| ▸ | TYK2 | P29597 | 1/20 | 0.54 |
| ▸ | ACP1 | P24666 | 2/20 | 0.53 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974148 | 0.88 | JAK2 (0.69) | JAK2JAK3PTK2JAK1TYK2 | |
| SCHEMBL7980038 | 0.85 | JAK2 (0.60) | JAK2JAK3PTK2JAK1TYK2 | |
| SCHEMBL7977326 | 0.85 | JAK2 (0.59) | JAK2JAK3PTK2JAK1TYK2 | |
| SCHEMBL7963973 | 0.82 | JAK2 (0.64) | JAK2JAK3PTK2JAK1TYK2 | |
| SCHEMBL13536681 | 0.82 | JAK2 (0.68) | JAK2JAK3PTK2JAK1TYK2 | |
| SCHEMBL13073243 | 0.81 | JAK2 (0.71) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL3214576 | 0.81 | JAK2 (0.63) | JAK2JAK3PTK2JAK1TYK2 | |
| SCHEMBL1423080 | 0.81 | JAK2 (0.77) | JAK2JAK3PTK2JAK1TYK2 | |
| SCHEMBL2640617 | 0.81 | JAK2 (0.85) | JAK2JAK3PTK2JAK1TYK2 | |
| SCHEMBL2640619 | 0.80 | JAK2 (1.00) | JAK2JAK3PTK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010188-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES. | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |