Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 12/20 | 0.59 |
| ▸ | JAK1 | P23458 | 7/20 | 0.56 |
| ▸ | JAK3 | P52333 | 6/20 | 0.55 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.55 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | IKBKB | O14920 | 1/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.47 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963973 | 0.95 | JAK2 (0.64) | JAK2JAK1JAK3PTK2CSF1R | |
| SCHEMBL7974148 | 0.91 | JAK2 (0.69) | JAK2JAK1JAK3PTK2IKBKB | |
| SCHEMBL3208514 | 0.86 | JAK2 (0.64) | JAK2JAK1JAK3PTK2CSF1R | |
| SCHEMBL7977595 | 0.85 | JAK2 (0.76) | JAK2JAK1JAK3PTK2IKBKB | |
| SCHEMBL7964535 | 0.85 | JAK2 (0.66) | JAK2JAK1JAK3PTK2TYK2 | |
| SCHEMBL2145108 | 0.84 | JAK2 (0.61) | JAK2JAK1JAK3PTK2 | |
| SCHEMBL3216367 | 0.83 | JAK2 (0.82) | JAK2JAK1JAK3PTK2IKBKB | |
| SCHEMBL7977614 | 0.80 | JAK1 (0.82) | JAK2JAK1JAK3PTK2IKBKB | |
| SCHEMBL13536665 | 0.79 | JAK2 (0.63) | JAK2JAK1JAK3PTK2KDM4E | |
| SCHEMBL2274423 | 0.79 | JAK2 (0.60) | JAK2JAK1JAK3PTK2IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010188-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES. | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |