Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 6/20 | 0.48 |
| ▸ | HTR3A | P46098 | 3/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7953666 | 0.89 | ELANE (0.58) | ELANEHTR3AADRB2TDP1TSHR | |
| SCHEMBL7966421 | 0.86 | ELANE (0.54) | ELANEHTR3AADRB2TDP1MEN1 | |
| SCHEMBL7960265 | 0.86 | ELANE (0.54) | ELANEHTR3AADRB2TDP1MEN1 | |
| SCHEMBL7966469 | 0.85 | ELANE (0.56) | ELANEHTR3AADRB2TDP1KDM4E | |
| SCHEMBL7954868 | 0.85 | ELANE (0.56) | ELANEHTR3ATDP1KDM4EMEN1 | |
| SCHEMBL7966257 | 0.85 | ELANE (0.53) | ELANEHTR3AADRB2TDP1ALDH1A1 | |
| SCHEMBL7966256 | 0.85 | ELANE (0.53) | ELANEHTR3AADRB2TDP1ALDH1A1 | |
| SCHEMBL7946372 | 0.85 | ELANE (0.55) | ELANEHTR3ATDP1MAPK1KDM4E | |
| SCHEMBL7960167 | 0.83 | ELANE (0.53) | ELANEADRB2TDP1TSHRMAPK1 | |
| SCHEMBL7969507 | 0.81 | ELANE (0.52) | ELANEADRB2TDP1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331548-B1 | PREVENTION OR TREATMENT OF CYTOKINE RELATED DISEASES | SUNTORY LIMITED (JP) | 2001-12-18 | — | — | US | disclosed |
| EP-0978516-A1 | 1-CYCLOALKYL-1,8-NAPHTHYRIDIN-4-ONE DERIVATIVES WITH PHOSPHODIESTERASE IV INHIBITORY ACTIVITY | SUNTORY LIMITED (JP) | 2000-02-09 | — | — | EP | disclosed |