Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 14/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 8/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.39 |
| ▸ | AURKC | Q9UQB9 | 2/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30566012 | 0.84 | HTR6 (0.48) | CYP3A4CYP2C9CYP2C19CYP2D6CYP1A2 | |
| SCHEMBL25246536 | 0.84 | HTR6 (0.48) | CYP3A4CYP2C9CYP2C19CYP2D6CYP1A2 | |
| SCHEMBL30275071 | 0.83 | CYP2D6 (0.43) | CYP3A4CYP2C9CYP2C19CYP2D6CYP1A2 | |
| SCHEMBL14197017 | 0.83 | CYP2D6 (0.43) | CYP3A4CYP2C19CYP2D6CYP1A2KDM4E | |
| SCHEMBL857144 | 0.83 | AURKA (0.47) | CYP3A4CYP2C19CYP2D6CYP1A2KDM4E | |
| SCHEMBL30068918 | 0.83 | AURKA (0.47) | CYP3A4CYP2C19CYP2D6CYP1A2KDM4E | |
| SCHEMBL1267965 | 0.83 | JAK2 (0.47) | CYP3A4CYP2C9CYP2C19CYP2D6CYP1A2 | |
| SCHEMBL12146866 | 0.81 | CYP3A4 (0.48) | CYP3A4CYP2C9CYP2C19MAP4K1KIT | |
| Iodide SCHEMBL25299428 | 0.81 | AURKA (0.46) | CYP3A4CYP2C19CYP2D6CYP1A2KDM4E | |
| Iodide SCHEMBL30068502 | 0.81 | AURKA (0.46) | CYP3A4CYP2C19CYP2D6CYP1A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100249118-A1 | protein kinase modulators such as Propane-1-sulfonic acid [2,4-difluoro-3-(5-ethoxy-1H-pyrrolo[1,3-b]pyridine-3-carbonyl)-phenyl]-amide, used to regulate signal transduction cascades, involved in the control of physiological functions including cellular growth and proliferation; anticarcinogenic agents | PLEXXIKON INC. | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249118-A1 | protein kinase modulators such as Propane-1-sulfonic acid [2,4-difluoro-3-(5-ethoxy-1H-pyrrolo[1,3-b]pyridine-3-carbonyl)-phenyl]-amide, used to regulate signal transduction cascades, involved in the control of physiological functions including cellular growth and proliferation; anticarcinogenic agents | MAP4K1, MAP4K2, MAP3K1 | CYP3A4 4851/4885CYP2C9 4869/4885CYP2C19 4868/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.