Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 3/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 5/20 | 0.33 |
| ▸ | DBF4 | Q9UBU7 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7967474 | 0.89 | HSP90AA1 (0.35) | DHODHIDO1TDP2CDC7DBF4 | |
| SCHEMBL7967142 | 0.89 | IDO1 (0.34) | DHODHIDO1TDP2CDC7DBF4 | |
| SCHEMBL7967747 | 0.88 | DHODH (0.38) | DHODHTDP2 | |
| SCHEMBL8328134 | 0.88 | DHODH (0.44) | DHODHIDO1 | |
| SCHEMBL7963830 | 0.88 | DHODH (0.36) | DHODHIDO1TDP2KDM4ENPC1 | |
| SCHEMBL7963937 | 0.87 | DHODH (0.37) | DHODH | |
| SCHEMBL7952777 | 0.87 | IDO1 (0.35) | DHODHIDO1TDP2CDC7DBF4 | |
| SCHEMBL7967763 | 0.86 | HCRTR1 (0.35) | IDO1TDP2CDC7DBF4KDM4E | |
| SCHEMBL8329745 | 0.81 | DHODH (0.38) | DHODHIDO1GSK3B | |
| SCHEMBL7963168 | 0.81 | GSK3B (0.32) | DHODHGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | claimed |
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | disclosed |