Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | SMO | Q99835 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7952188 | 0.89 | IDO1 (0.35) | IDO1TDP2DHODHHSP90AA1HSP90B1 | |
| SCHEMBL7962686 | 0.89 | DHODH (0.32) | TDP2SMOHCRTR1DHODH | |
| SCHEMBL8325506 | 0.88 | DHODH (0.36) | IDO1ABL1SMODHODH | |
| SCHEMBL7965052 | 0.87 | DHODH (0.36) | IDO1ABL1TDP2CDC7DBF4 | |
| SCHEMBL7961614 | 0.87 | PLAU (0.34) | DHODH | |
| SCHEMBL7967474 | 0.86 | HSP90AA1 (0.35) | IDO1TDP2CDC7DBF4BDKRB1 | |
| SCHEMBL7967142 | 0.86 | IDO1 (0.34) | IDO1ABL1TDP2CYP1A2CDC7 | |
| SCHEMBL7967763 | 0.83 | HCRTR1 (0.35) | IDO1ABL1TDP2CYP1A2HTR2A | |
| SCHEMBL7965769 | 0.81 | CFTR (0.41) | CYP1A2HTR2AHTR2CHTR2BALDH1A1 | |
| SCHEMBL8329745 | 0.79 | DHODH (0.38) | IDO1GSK3BDHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | disclosed |