Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 16/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.69 |
| ▸ | FPR3 | P25089 | 2/20 | 0.67 |
| ▸ | TSPO | P30536 | 2/20 | 0.67 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5599759 | 0.93 | CRHR1 (0.87) | CRHR1TDP1FPR3TSPOTMEM97 | |
| SCHEMBL5599498 | 0.84 | CRHR1 (0.72) | CRHR1TDP1FPR3TSPOTMEM97 | |
| SCHEMBL7628525 | 0.84 | CRHR1 (0.72) | CRHR1TDP1FPR3TSPOTMEM97 | |
| Antalarmin SCHEMBL466243 | 0.82 | CRHR1 (1.00) | CRHR1TDP1FPR3TSPOTMEM97 | |
| Antalarmin SCHEMBL29832078 | 0.82 | CRHR1 (1.00) | CRHR1TDP1FPR3TSPOTMEM97 | |
| Antalarmin SCHEMBL25395568 | 0.81 | CRHR1 (0.98) | CRHR1TDP1FPR3TSPOTMEM97 | |
| Antalarmin SCHEMBL29601552 | 0.81 | CRHR1 (0.98) | CRHR1TDP1FPR3TSPOTMEM97 | |
| Cp-154526 SCHEMBL5707848 | 0.81 | CRHR1 (1.00) | CRHR1TDP1FPR3TSPOTMEM97 | |
| Cp-154526 SCHEMBL29706373 | 0.81 | CRHR1 (1.00) | CRHR1TDP1FPR3TSPOTMEM97 | |
| Cp-154526 SCHEMBL31012286 | 0.80 | CRHR1 (1.00) | CRHR1TDP1FPR3TSPOTMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218397-B1 | FOR THERAPY OF STRESS-RELATED ILLNESSES, SUCH AS STRESS-INDUCED DEPRESSION, ANXIETY, AND HEADACHE; ABDOMINAL BOWEL SYNDROME; INFLAMMATORY DISEASES; IMMUNE SUPPRESSION; ALZHEIMER'S DISEASE; GASTRONINTESTINAL DISEASES | PFIZER INC | 2001-04-17 | — | — | US | disclosed |
| EP-0674642-B1 | PYRAZOLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER (US) | 2000-08-23 | — | — | EP | disclosed |