Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.65 |
| ▸ | CD38 | P28907 | 1/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13151521 | 0.82 | RET (0.60) | EGFRCD38FLT1KDRPTK2 | |
| SCHEMBL17967501 | 0.81 | EGFR (0.68) | EGFRFLT1KDREPHX2RET | |
| SCHEMBL6837745 | 0.79 | EGFR (1.00) | EGFR | |
| SCHEMBL868674 | 0.79 | EGFR (0.59) | EGFRCD38KDRRET | |
| SCHEMBL7981320 | 0.78 | EGFR (0.73) | EGFRCD38KDRCYP1A2CYP3A4 | |
| SCHEMBL5864606 | 0.78 | EGFR (1.00) | EGFRFLT1KDRRET | |
| SCHEMBL30140108 | 0.77 | EGFR (0.65) | EGFRFLT1KDR | |
| SCHEMBL7965118 | 0.76 | EGFR (0.73) | EGFRCD38KDRTSHR | |
| SCHEMBL17967497 | 0.73 | EGFR (0.74) | EGFRFLT1KDRRET | |
| SCHEMBL18354383 | 0.72 | EGFR (0.65) | EGFRCD38USP2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313292-B1 | REACTION FROM 5-AMINO-2-FLUOROPYRIDINE; AMINATION, CYCLIZATION, CHLORINATION, SALT FORMATION, DECHLORINATION, DEBLOCKING | WARNER-LAMBERT COMPANY | 2001-11-06 | — | — | US | disclosed |
| WO-1997026259-A1 | IMPROVED PROCESS FOR PREPARING 4,6-DISUBSTITUTED PYRIDO[3,4-d]PYRIMIDINES | WARNER-LAMBERT COMPANY (US) | 1997-07-24 | — | — | WO | disclosed |