Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | PLG | P00747 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | PLAT | P00750 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7965284 | 1.00 | DRD2 (0.41) | DRD2DRD4DRD3GRM2KDM4E | |
| SCHEMBL10365484 | 1.00 | DRD2 (0.41) | DRD2DRD4DRD3GRM2KDM4E | |
| SCHEMBL1545124 | 0.80 | KDM4E (0.49) | DRD2DRD4DRD3GRM2KDM4E | |
| Hydrochloric Acid SCHEMBL1838069 | 0.79 | KDM4E (0.51) | DRD2DRD4DRD3GRM2KDM4E | |
| SCHEMBL8207212 | 0.75 | HTR2A (0.41) | DRD2DRD4DRD3GRM2KDM4E | |
| SCHEMBL9020129 | 0.72 | DRD2 (0.47) | DRD2DRD4DRD3GRM2KDM4E | |
| SCHEMBL4558894 | 0.72 | HTR2A (0.44) | DRD2DRD4DRD3GRM2KDM4E | |
| SCHEMBL2204018 | 0.72 | DRD2 (0.46) | DRD2DRD4DRD3GRM2KDM4E | |
| SCHEMBL1840347 | 0.72 | DRD2 (0.58) | DRD2DRD4DRD3GRM2KDM4E | |
| Hydrochloric Acid SCHEMBL8230683 | 0.71 | DRD2 (0.46) | DRD2DRD4DRD3GRM2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| WO-1999065487-A1 | INHIBITORS OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |