SCHEMBL7965577

SCHEMBL7965577

OCc1ccc(CCc2ccncc2)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LOXL2 Q9Y4K0 2/20 0.52
CHKA P35790 1/20 0.47
HRH3 Q9Y5N1 2/20 0.45
MKNK1 Q9BUB5 1/20 0.45
MKNK2 Q9HBH9 1/20 0.45
HRH4 Q9H3N8 1/20 0.45
PRKCI P41743 1/20 0.45
HRH1 P35367 2/20 0.45
CYP11B1 P15538 2/20 0.44
CYP11B2 P19099 1/20 0.44
CYP1A2 P05177 3/20 0.42
CYP3A4 P08684 3/20 0.42
CYP2D6 P10635 3/20 0.42
CYP2C9 P11712 3/20 0.42
CYP2C19 P33261 3/20 0.42
ALDH1A1 P00352 1/20 0.42
HSD17B10 Q99714 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
TSHR P16473 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pyridine 4-Methanol SCHEMBL102606 0.89
Pyridine 4-Methanol SCHEMBL28178737 0.87
Pyridine 4-Methanol SCHEMBL4445081 0.87
Pyridine 4-Methanol SCHEMBL26112701 0.87
Pyridine 4-Methanol SCHEMBL28294333 0.87
SCHEMBL151822 0.84 LOXL2 (0.68) LOXL2HRH3HRH4HRH1CYP11B1
SCHEMBL7539245 0.84 CHKA (0.58) CHKAMKNK1MKNK2TDP1TSHR
Pyridine 4-Methanol SCHEMBL28182518 0.82 CYP1A2 (0.47) LOXL2HRH3MKNK1MKNK2PRKCI
Pyridine 4-Methanol SCHEMBL10842741 0.82 PRKCI (0.47) LOXL2MKNK1MKNK2PRKCICYP11B1
Water SCHEMBL31124597 0.81 LOXL2 (0.65) LOXL2HRH3HRH4HRH1CYP11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6194396-B1 ANTIALLERGENS; ANTIINFLAMMATION AGENTS; AUTOIMMUNE DISEASE; ANTISHOCK AGENTS; ANALGESICS; E.G., A 4 OR 7-PHENYLALKYLENE-OXYBENZIMIDAZOLE UNSUBSTITUTED OR SUBSTITUTED IN THE 1,2,3-POSITION WITH AN OXY, AMINO AND/OR THIO GROUP FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-02-27 US disclosed
US-6083961-A FOR PREVENTION AND/OR TREATMENT OF BRADYKININ OR ITS ANALOGUES MEDIATED DISEASES SUCH AS ALLERGY, INFLAMMATION, AUTOIMMUNE DISEASE, SHOCK, PAIN FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2000-07-04 US disclosed
EP-0774462-A1 HETEROCYCLIC COMPOUND FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-05-21 EP disclosed