Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.37 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.37 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7965664 | 1.00 | TSHR (0.37) | TSHRPLA2G10PLA2G1BPLA2G2APLA2G5 | |
| SCHEMBL11033646 | 0.82 | TSHR (0.41) | TSHRRAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL1979106 | 0.78 | CYP2A6 (0.48) | TSHRRAB9ACYP2A6MAOBNPC1 | |
| SCHEMBL5319833 | 0.77 | CYP2A6 (0.42) | TSHRRAB9ACYP2A6MAOBALOX5 | |
| SCHEMBL18186635 | 0.75 | TSHR (0.47) | TSHRRAB9ANPC1SMN1; SMN2AR | |
| SCHEMBL5319832 | 0.73 | CYP2A6 (0.41) | TSHRRAB9ACYP2A6MAOBNPC1 | |
| SCHEMBL8456770 | 0.72 | POLB (0.49) | TSHRRAB9ACYP2A6MAOBCYP19A1 | |
| SCHEMBL2608936 | 0.72 | CYP2A6 (0.48) | TSHRRAB9ACYP2A6MAOBALOX5 | |
| SCHEMBL2057880 | 0.71 | ALDH1A1 (0.43) | TSHRALDH1A1 | |
| SCHEMBL9613931 | 0.71 | KMT2A (0.43) | TSHRNPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6274715-B1 | SEMISYNTHETIC MACROLIDES, USEFUL IN BACTERIAL INFECTIONS TREATMENT AND PREVENTION, HAS LESS POTENTIAL FOR DEVELOPING RESISTANCE, IMPROVED OR MODIFIED PROFILES OF DESIRED GRAM-NEGATIVE ACTIVITY | ABBOTT LABORATORIES | 2001-08-14 | — | — | US | disclosed |