Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 11/20 | 0.66 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.42 |
| ▸ | PYGL | P06737 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5753435 | 0.85 | OPRM1 (0.66) | OPRM1OPRD1OPRK1ADRA2AAR | |
| SCHEMBL5751643 | 0.85 | OPRM1 (0.66) | OPRM1OPRD1OPRK1SIGMAR1ADRA2A | |
| SCHEMBL5754673 | 0.85 | OPRM1 (0.66) | OPRM1OPRD1OPRK1SIGMAR1ADRA2A | |
| SCHEMBL5754727 | 0.82 | OPRM1 (0.62) | OPRM1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL5753484 | 0.80 | OPRM1 (1.00) | OPRM1OPRD1OPRK1KCNH2 | |
| SCHEMBL5754694 | 0.79 | OPRM1 (0.83) | OPRM1OPRD1OPRK1KCNH2 | |
| Hydrochloric Acid SCHEMBL5756166 | 0.79 | OPRM1 (0.98) | OPRM1OPRD1OPRK1KCNH2 | |
| SCHEMBL5759759 | 0.78 | OPRM1 (0.81) | OPRM1OPRD1OPRK1HTR2AKCNH2 | |
| SCHEMBL5757308 | 0.78 | OPRM1 (0.81) | OPRM1OPRD1OPRK1KCNH2 | |
| SCHEMBL5754744 | 0.78 | OPRM1 (0.57) | OPRM1OPRD1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313312-B1 | OPIATE RECEPTOR BINDERS; ALLERGIC DERMATITIS, PRURITUS; IRRITABLE BOWEL SYNDROME, GASTROINTESTINAL AND SKIN DISORDERS; VETERINARY MEDICINE; ANTI-ITCHING | PFIZER INC | 2001-11-06 | — | — | US | disclosed |