Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 6/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8220313 | 0.78 | POLB (0.45) | LMNASMN1; SMN2NR2F2HTTGAA | |
| SCHEMBL8220319 | 0.76 | LMNA (0.47) | LMNASMN1; SMN2NR2F2HTTGAA | |
| SCHEMBL8236007 | 0.73 | GAA (0.43) | LMNASMN1; SMN2NR2F2HTTGAA | |
| SCHEMBL7966282 | 0.71 | GAA (0.43) | LMNASMN1; SMN2NR2F2HTTGAA | |
| SCHEMBL8217267 | 0.70 | KMT2A (0.35) | LMNASMN1; SMN2NR2F2HTTPKM | |
| SCHEMBL14758387 | 0.66 | SMN1; SMN2 (1.00) | LMNASMN1; SMN2NR2F2HTTGAA | |
| SCHEMBL5960099 | 0.64 | GAA (1.00) | LMNASMN1; SMN2HTTGAAPOLB | |
| SCHEMBL3557383 | 0.62 | MAPT (0.67) | SMN1; SMN2GAAPOLBTSHRGFER | |
| SCHEMBL8195511 | 0.61 | HTT (0.55) | LMNASMN1; SMN2HTTPKMPOLB | |
| SCHEMBL94670 | 0.61 | GAA (0.71) | LMNASMN1; SMN2HTTGAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6255323-B1 | Cyanoguanidine compounds | SHIONOGI BIORESEARCH CORP. | 2001-07-03 | — | — | US | claimed |
| WO-2000061561-A1 | CYANOGUANIDINE COMPOUNDS | SHIONOGI BIORESEARCH CORP. (US) | 2000-10-19 | — | — | WO | claimed |
| US-6255323-B1 | Cyanoguanidine compounds | SHIONOGI BIORESEARCH CORP. | 2001-07-03 | — | — | US | disclosed |