SCHEMBL7966339

SCHEMBL7966339

CC[C@@H](CO)Oc1ccc(Br)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LDHA P00338 1/20 0.44
SLC6A4 P31645 1/20 0.37
CYP2C9 P11712 1/20 0.37
TSHR P16473 1/20 0.37
KDM4E B2RXH2 4/20 0.36
TDP1 Q9NUW8 3/20 0.36
MAPK1 P28482 3/20 0.36
PPARG P37231 1/20 0.36
PPARA Q07869 1/20 0.36
MEN1 O00255 4/20 0.36
KMT2A Q03164 4/20 0.36
ALDH1A1 P00352 3/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
MAPT P10636 3/20 0.36
GAA P10253 2/20 0.36
LMNA P02545 2/20 0.36
HPGD P15428 1/20 0.36
HTT P42858 1/20 0.36
RAB9A P51151 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12953262 0.88 LDHA (0.45) LDHASLC6A4KDM4ETDP1MAPK1
SCHEMBL11128487 0.82 MAPT (0.41) CYP2C9TSHRPPARGPPARAMEN1
SCHEMBL11124600 0.82 CYP2C9 (0.55) LDHACYP2C9TSHRPPARGPPARA
SCHEMBL7806642 0.81 LDHA (0.44) LDHASLC6A4CYP2C9TSHRTDP1
SCHEMBL11946586 0.81 PPARG (0.42) CYP2C9TSHRPPARGPPARAGAA
SCHEMBL21057195 0.81 LDHA (0.44) LDHASLC6A4CYP2C9TSHRKDM4E
SCHEMBL10875177 0.81 PPARG (0.43) CYP2C9TSHRPPARGPPARAGAA
SCHEMBL21057198 0.81 LDHA (0.44) LDHASLC6A4CYP2C9TSHRKDM4E
SCHEMBL1305344 0.81 SLC6A4 (0.41) LDHASLC6A4KDM4ETDP1MAPK1
SCHEMBL166063 0.80 CDK5 (0.41) SLC6A4TSHRKDM4EPPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6300352-B1 FOR THERAPY OF ASTHMA ASTRAZENECA AB (SE) 2001-10-09 US disclosed
EP-0971892-A1 NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Astra Pharmaceuticals Limited (GB) 2000-01-19 EP disclosed
WO-1998042670-A1 NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM ASTRA PHARMACEUTICALS LTD. (GB) 1998-10-01 WO disclosed