Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.37 |
| ▸ | PTGES | O14684 | 7/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7966353 | 0.93 | TSHR (0.38) | BRD4PTGESTSHRMAPK10PARP1 | |
| SCHEMBL7969777 | 0.90 | JAK2 (0.39) | BRD4PARP1 | |
| SCHEMBL7482373 | 0.90 | BRD4 (0.34) | BRD4PTGESTSHRMAPK10HDAC1 | |
| SCHEMBL7585746 | 0.90 | PTGES (0.40) | BRD4PTGESTSHRMAPK10PARP1 | |
| SCHEMBL7964884 | 0.90 | BRD4 (0.35) | BRD4PTGESTSHRMAPK10PARP1 | |
| SCHEMBL7607734 | 0.89 | BRD4 (0.35) | BRD4PTGESTSHRMAPK10PARP1 | |
| SCHEMBL7483103 | 0.89 | BRD4 (0.36) | BRD4PTGESTSHRMAPK10HDAC1 | |
| SCHEMBL7476090 | 0.88 | BRD4 (0.41) | BRD4PTGESTP53GAA | |
| SCHEMBL7965806 | 0.88 | BRD4 (0.34) | BRD4PTGESTSHRMAPK10HDAC1 | |
| SCHEMBL7479422 | 0.88 | BRD4 (0.35) | BRD4PTGESTSHRMAPK10HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6207693-B1 | Benzamide derivatives having a vasopressin antagonistic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |