Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 14/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7966595 | 1.00 | PTAFR (0.48) | PTAFRPOLBHPGDABL1ALDH1A1 | |
| SCHEMBL7980074 | 0.86 | PTAFR (0.51) | PTAFRPOLBHPGDALDH1A1LMNA | |
| SCHEMBL7980076 | 0.86 | PTAFR (0.51) | PTAFRPOLBHPGDALDH1A1LMNA | |
| SCHEMBL7979957 | 0.84 | CYP11B1 (0.44) | PTAFR | |
| SCHEMBL7979919 | 0.84 | CYP11B1 (0.44) | PTAFR | |
| SCHEMBL7966313 | 0.83 | PTAFR (0.45) | PTAFRPOLBHPGD | |
| SCHEMBL7966315 | 0.83 | PTAFR (0.45) | PTAFRPOLBHPGD | |
| SCHEMBL7980472 | 0.81 | LRRK2 (0.43) | PTAFRPOLBHPGDALDH1A1LMNA | |
| SCHEMBL7980467 | 0.81 | LRRK2 (0.43) | PTAFRPOLBHPGDALDH1A1LMNA | |
| SCHEMBL7976720 | 0.79 | KCNK3 (0.43) | PTAFRPOLBHPGDLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6300352-B1 | FOR THERAPY OF ASTHMA | ASTRAZENECA AB (SE) | 2001-10-09 | — | — | US | claimed |
| US-6300352-B1 | FOR THERAPY OF ASTHMA | ASTRAZENECA AB (SE) | 2001-10-09 | — | — | US | disclosed |