Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 7/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | GPR132 | Q9UNW8 | 6/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7980074 | 1.00 | PTAFR (0.51) | PTAFRMEN1LMNAKMT2ATDP1 | |
| SCHEMBL7978309 | 0.89 | PTAFR (0.48) | PTAFRMKNK1MKNK2POLBHPGD | |
| SCHEMBL7978928 | 0.89 | PTAFR (0.48) | PTAFRMKNK1MKNK2POLBHPGD | |
| SCHEMBL7979959 | 0.87 | PTAFR (0.47) | PTAFRLMNAPOLBHPGDHTT | |
| SCHEMBL7979963 | 0.87 | PTAFR (0.47) | PTAFRLMNAPOLBHPGDHTT | |
| SCHEMBL7966595 | 0.86 | PTAFR (0.48) | PTAFRMEN1LMNAKMT2ATDP1 | |
| SCHEMBL7966593 | 0.86 | PTAFR (0.48) | PTAFRMEN1LMNAKMT2ATDP1 | |
| SCHEMBL7980129 | 0.83 | PTAFR (0.42) | PTAFRLMNAPOLBHPGDCYP3A4 | |
| SCHEMBL7966197 | 0.83 | PTAFR (0.42) | PTAFRLMNAPOLBHPGDCYP3A4 | |
| SCHEMBL7976881 | 0.83 | PTAFR (0.42) | PTAFRLMNAPOLBHPGDCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6300352-B1 | FOR THERAPY OF ASTHMA | ASTRAZENECA AB (SE) | 2001-10-09 | — | — | US | claimed |
| EP-0971892-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Astra Pharmaceuticals Limited (GB) | 2000-01-19 | — | — | EP | claimed |
| WO-1998042670-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRA PHARMACEUTICALS LTD. (GB) | 1998-10-01 | — | — | WO | claimed |
| US-6300352-B1 | FOR THERAPY OF ASTHMA | ASTRAZENECA AB (SE) | 2001-10-09 | — | — | US | disclosed |