⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7967438 | 0.71 | — | — | |
| SCHEMBL1721873 | 0.71 | — | — | |
| SCHEMBL1266955 | 0.71 | — | — | |
| SCHEMBL8392401 | 0.69 | — | — | |
| SCHEMBL3064649 | 0.69 | — | — | |
| SCHEMBL18160818 | 0.69 | ALDH1A1 (0.39) | — | |
| SCHEMBL14898520 | 0.69 | — | — | |
| SCHEMBL11179202 | 0.69 | — | — | |
| SCHEMBL21216043 | 0.69 | — | — | |
| SCHEMBL21447991 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230172977-A1 | THERAPEUTIC METAL COMPLEXES AND LIGANDS AND METHODS OF MAKING AND USING THE SAME | OREGON STATE UNIVERSITY (US) | 2023-06-08 | — | — | US | disclosed |
| US-8748451-B2 | HDAC inhibitors and therapeutic methods of using same | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2014-06-10 | — | — | US | disclosed |
| US-20140128408-A1 | HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2014-05-08 | — | — | US | disclosed |
| US-20130281484-A1 | HDAC Inhibitors and Therapeutic Methods of Using Same | UNIV ILLINOIS (US) | 2013-10-24 | — | — | US | disclosed |
| US-8431538-B2 | HDAC inhibitors and therapeutic methods of using same | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2013-04-30 | — | — | US | disclosed |
| WO-2012106343-A2 | HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2012-08-09 | — | — | WO | disclosed |
| WO-2011011186-A2 | HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2011-01-27 | — | — | WO | disclosed |
| WO-2010017272-A2 | METHOD OF TREATING NEUROLOGICAL DISEASES | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2010-02-11 | — | — | WO | disclosed |
| EP-0515121-B1 | Process for preparing intermediates to nizatidine and related compounds | LILLY CO ELI (US) | 2000-11-02 | — | — | EP | disclosed |
| EP-0960880-A1 | Process for preparing intermediates to nizatidine and related compounds | ELI LILLY AND COMPANY (US) | 1999-12-01 | — | — | EP | disclosed |
| US-5457206-A | Reacting a 4-hydroxy-4-chloromethyl-2-(aminomethyl)thiazoline with an alkali metal compound in an inert solvents to dechlorination | ELI LILLY AND COMPANY (US) | 1995-10-10 | — | — | US | disclosed |
| US-5334725-A | 2-aminomethyl-4-exomethylenethiazoline epoxides | ELI LILLY AND COMPANY (US) | 1994-08-02 | — | — | US | disclosed |
| EP-0515121-A1 | Process for preparing intermediates to nizatidine and related compounds | ELI LILLY AND COMPANY (US) | 1992-11-25 | — | — | EP | disclosed |