Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 9/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7966814 | 1.00 | TACR1 (0.55) | TACR1CYP19A1ALDH1A1TAAR1CA1 | |
| SCHEMBL7889540 | 0.77 | ALDH1A1 (0.58) | TACR1CYP19A1ALDH1A1ABCB1 | |
| SCHEMBL8965718 | 0.75 | TACR1 (0.70) | TACR1 | |
| SCHEMBL2937484 | 0.74 | ALDH1A1 (0.44) | TACR1CYP19A1ALDH1A1TAAR1ABCB1 | |
| SCHEMBL24496970 | 0.73 | TACR1 (0.49) | TACR1CYP19A1ALDH1A1TAAR1 | |
| SCHEMBL29711723 | 0.73 | TACR1 (0.49) | TACR1CYP19A1ALDH1A1TAAR1 | |
| SCHEMBL22425944 | 0.73 | TACR1 (0.49) | TACR1CYP19A1ALDH1A1TAAR1 | |
| SCHEMBL29711846 | 0.73 | TACR1 (0.49) | TACR1CYP19A1ALDH1A1TAAR1 | |
| SCHEMBL2781643 | 0.72 | TACR1 (0.59) | TACR1CA1CA2 | |
| SCHEMBL7965700 | 0.72 | TACR1 (0.59) | TACR1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6274715-B1 | SEMISYNTHETIC MACROLIDES, USEFUL IN BACTERIAL INFECTIONS TREATMENT AND PREVENTION, HAS LESS POTENTIAL FOR DEVELOPING RESISTANCE, IMPROVED OR MODIFIED PROFILES OF DESIRED GRAM-NEGATIVE ACTIVITY | ABBOTT LABORATORIES | 2001-08-14 | — | — | US | disclosed |
| EP-0961776-A1 | TRICYCLIC ERYTHROMYCIN DERIVATIVES | Abbott Laboratories (US) | 1999-12-08 | — | — | EP | disclosed |
| WO-1998030574-A1 | TRICYCLIC ERYTHROMYCIN DERIVATIVES | ABBOTT LABORATORIES (US) | 1998-07-16 | — | — | WO | disclosed |