Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.38 |
| ▸ | LSS | P48449 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7964234 | 1.00 | CYP2D6 (0.53) | CYP2D6CYP1A2HRH3MEN1KMT2A | |
| SCHEMBL8630790 | 1.00 | CYP2D6 (0.53) | CYP2D6CYP1A2HRH3MEN1KMT2A | |
| SCHEMBL30773845 | 0.79 | CYP2D6 (0.45) | CYP2D6CYP1A2MEN1KMT2AMAPT | |
| SCHEMBL2342353 | 0.79 | CYP2D6 (0.52) | CYP2D6CYP1A2MEN1KMT2AACACB | |
| SCHEMBL3388527 | 0.77 | CYP2D6 (0.74) | CYP2D6CYP1A2KMT2AL3MBTL1CYP2C19 | |
| SCHEMBL420300 | 0.77 | CYP2D6 (0.74) | CYP2D6CYP1A2KMT2AL3MBTL1CYP2C19 | |
| SCHEMBL31342336 | 0.77 | CYP2D6 (0.59) | CYP2D6CYP1A2MEN1KMT2AMAPT | |
| SCHEMBL2405904 | 0.76 | CYP2D6 (0.52) | CYP2D6CYP1A2MEN1KMT2AMAPT | |
| SCHEMBL2405905 | 0.76 | CYP2D6 (0.52) | CYP2D6CYP1A2MEN1KMT2AMAPT | |
| SCHEMBL1410427 | 0.76 | MEN1 (0.53) | CYP2D6CYP1A2MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |