Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | KDM1A | O60341 | 8/20 | 0.56 |
| ▸ | MAOA | P21397 | 5/20 | 0.56 |
| ▸ | MAOB | P27338 | 2/20 | 0.56 |
| ▸ | RCOR1 | Q9UKL0 | 5/20 | 0.55 |
| ▸ | MGLL | Q99685 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.49 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7966954 | 1.00 | POLB (0.58) | POLBTP53MAPTKDM1AMAOA | |
| SCHEMBL6051669 | 0.86 | SLC7A5 (0.59) | POLBTP53MAPTKDM1AMAOA | |
| SCHEMBL6051665 | 0.86 | SLC7A5 (0.59) | POLBTP53MAPTKDM1AMAOA | |
| SCHEMBL15947583 | 0.84 | POLB (0.50) | POLBTP53MAPTKDM1AMAOA | |
| SCHEMBL14055557 | 0.83 | POLB (0.68) | POLBTP53MAPTKDM1AMAOA | |
| SCHEMBL9080564 | 0.83 | POLB (0.68) | POLBTP53MAPTKDM1AMAOA | |
| SCHEMBL7217283 | 0.82 | POLB (0.59) | POLBTP53MAPTKDM1AMAOA | |
| SCHEMBL3942525 | 0.81 | POLB (0.66) | POLBTP53MAPTKDM1AMAOA | |
| SCHEMBL10598558 | 0.81 | POLB (0.69) | POLBTP53MAPTKDM1AMAOA | |
| Benzyl Phenylcarbamate SCHEMBL1222943 | 0.81 | POLB (0.78) | POLBTP53MAPTKDM1AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6274715-B1 | SEMISYNTHETIC MACROLIDES, USEFUL IN BACTERIAL INFECTIONS TREATMENT AND PREVENTION, HAS LESS POTENTIAL FOR DEVELOPING RESISTANCE, IMPROVED OR MODIFIED PROFILES OF DESIRED GRAM-NEGATIVE ACTIVITY | ABBOTT LABORATORIES | 2001-08-14 | — | — | US | disclosed |
| CN-1244202-A | Tricyclic erythromycin derivatives | ABBOTT LAB (US) | 2000-02-09 | — | — | CN | disclosed |
| EP-0961776-A1 | TRICYCLIC ERYTHROMYCIN DERIVATIVES | Abbott Laboratories (US) | 1999-12-08 | — | — | EP | disclosed |
| WO-1998030574-A1 | TRICYCLIC ERYTHROMYCIN DERIVATIVES | ABBOTT LABORATORIES (US) | 1998-07-16 | — | — | WO | disclosed |