Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | KDM1A | O60341 | 3/20 | 0.54 |
| ▸ | MAOA | P21397 | 2/20 | 0.54 |
| ▸ | MAOB | P27338 | 2/20 | 0.54 |
| ▸ | MGLL | Q99685 | 1/20 | 0.53 |
| ▸ | RCOR1 | Q9UKL0 | 2/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.50 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7217491 | 0.89 | POLB (0.57) | POLBTP53MAPTKDM1AMAOA | |
| SCHEMBL6051669 | 0.85 | SLC7A5 (0.59) | POLBTP53MAPTKDM1AMAOA | |
| SCHEMBL6051665 | 0.85 | SLC7A5 (0.59) | POLBTP53MAPTKDM1AMAOA | |
| SCHEMBL7357956 | 0.84 | ITGB3 (0.61) | KDM1AMAOAMAOBRCOR1 | |
| SCHEMBL22402969 | 0.84 | SMN1; SMN2 (0.59) | POLBTP53MAPTKDM1AMAOA | |
| SCHEMBL21552129 | 0.84 | SMN1; SMN2 (0.59) | POLBTP53MAPTKDM1AMAOA | |
| SCHEMBL7966954 | 0.82 | POLB (0.58) | POLBTP53MAPTKDM1AMAOA | |
| SCHEMBL7966946 | 0.82 | POLB (0.58) | POLBTP53MAPTKDM1AMAOA | |
| SCHEMBL10598558 | 0.82 | POLB (0.69) | POLBTP53MAPTKDM1AMAOA | |
| Benzyl Phenylcarbamate SCHEMBL1222943 | 0.82 | POLB (0.78) | POLBTP53MAPTKDM1AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6531604-B2 | Useful as medicines having an osteogenesis promoting effect and chondrogensis promoting effect. | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-03-11 | — | — | US | disclosed |
| US-20020128308-A1 | Benzothiepine derivatives, their production and use | YASUMA TSUNEO (JP) | 2002-09-12 | — | — | US | disclosed |
| US-6355672-B1 | BONE DISORDERS; CENTRAL NERVOUS SYSTEM DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-03-12 | — | — | US | disclosed |
| EP-1103552-A1 | BENZOTHIEPIN DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2001-05-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020128308-A1 | Benzothiepine derivatives, their production and use | APP, BMP1, BACE1 | POLB 3851/4885TP53 2752/4885MAPT 331/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.