Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7964608 | 0.96 | ALK (0.34) | KDREGFRHDAC1FGFR3ALK | |
| Hydrochloric Acid SCHEMBL7472559 | 0.96 | ALK (0.34) | KDREGFRHDAC1FGFR3ALK | |
| SCHEMBL7967130 | 0.95 | CACNA1G (0.33) | HDAC1ALK | |
| SCHEMBL7954417 | 0.95 | MLLT1 (0.34) | ALDH1A1LMNAHDAC1ALK | |
| SCHEMBL7485529 | 0.94 | IRAK4 (0.36) | CD274PDCD1IRAK4MAPK14KDR | |
| SCHEMBL7966975 | 0.93 | KDM4E (0.35) | CD274PDCD1IRAK4MAPK14KDR | |
| Hydrochloric Acid SCHEMBL7978179 | 0.93 | KDM4E (0.35) | CD274PDCD1IRAK4MAPK14KDR | |
| SCHEMBL7964677 | 0.92 | HDAC3 (0.34) | KDREGFRHDAC1 | |
| SCHEMBL7480416 | 0.91 | ABCB1 (0.34) | KDREGFRHDAC1 | |
| Hydrochloric Acid SCHEMBL7963051 | 0.91 | HDAC3 (0.34) | KDREGFRHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |