Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 13/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | APLNR | P35414 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | AGXT | P21549 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14453244 | 0.90 | APLNR (0.40) | TBXAS1CA1CA2APLNRIDO1 | |
| SCHEMBL2211396 | 0.80 | APLNR (0.40) | APLNRPOLBMMP3 | |
| SCHEMBL2211391 | 0.80 | APLNR (0.40) | APLNRPOLBMMP3 | |
| SCHEMBL30950123 | 0.78 | CA1 (0.59) | TBXAS1CA1CA2IDO1AGXT | |
| SCHEMBL14538694 | 0.78 | CA1 (0.59) | TBXAS1CA1CA2IDO1AGXT | |
| SCHEMBL7955616 | 0.78 | CA1 (0.59) | TBXAS1CA1CA2IDO1AGXT | |
| SCHEMBL15890496 | 0.74 | CA1 (0.46) | TBXAS1CA1CA2APLNRIDO1 | |
| SCHEMBL21647830 | 0.72 | CA1 (0.49) | TBXAS1CA1CA2IDO1AGXT | |
| SCHEMBL8183423 | 0.72 | CA1 (0.49) | TBXAS1CA1CA2IDO1AGXT | |
| SCHEMBL4982796 | 0.72 | CA1 (0.41) | CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6274715-B1 | SEMISYNTHETIC MACROLIDES, USEFUL IN BACTERIAL INFECTIONS TREATMENT AND PREVENTION, HAS LESS POTENTIAL FOR DEVELOPING RESISTANCE, IMPROVED OR MODIFIED PROFILES OF DESIRED GRAM-NEGATIVE ACTIVITY | ABBOTT LABORATORIES | 2001-08-14 | — | — | US | disclosed |
| EP-0961776-A1 | TRICYCLIC ERYTHROMYCIN DERIVATIVES | Abbott Laboratories (US) | 1999-12-08 | — | — | EP | disclosed |
| WO-1998030574-A1 | TRICYCLIC ERYTHROMYCIN DERIVATIVES | ABBOTT LABORATORIES (US) | 1998-07-16 | — | — | WO | disclosed |