Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 17/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 16/20 | 0.49 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.46 |
| ▸ | TUBB | P07437 | 1/20 | 0.46 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.46 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.46 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.46 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.46 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.46 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.46 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.46 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.46 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.46 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.46 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.46 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.46 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8310884 | 0.95 | ESR1 (0.52) | ESR1ESR2MEN1KMT2ATDP1 | |
| SCHEMBL7971635 | 0.95 | TUBB4A (0.50) | ESR1ESR2TUBB4ATUBBTUBA3C | |
| SCHEMBL7968881 | 0.90 | ESR1 (0.49) | ESR1ESR2TUBB4ATUBBTUBA3C | |
| SCHEMBL21633429 | 0.83 | ESR1 (0.57) | ESR1ESR2MEN1KMT2ATDP1 | |
| SCHEMBL6836408 | 0.81 | ESR1 (0.55) | ESR1ESR2MEN1KMT2ATDP1 | |
| SCHEMBL7075664 | 0.78 | ESR1 (0.74) | ESR1ESR2TUBB4ATUBBTUBA3C | |
| SCHEMBL7075631 | 0.78 | ESR1 (0.74) | ESR1ESR2TUBB4ATUBBTUBA3C | |
| SCHEMBL1665792 | 0.78 | CNR1 (0.70) | ESR1ESR2TUBB4ATUBBTUBA3C | |
| SCHEMBL7075354 | 0.78 | CNR1 (0.70) | ESR1ESR2TUBB4ATUBBTUBA3C | |
| SCHEMBL6835772 | 0.78 | ESR1 (0.53) | ESR1ESR2MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291484-B1 | TREATMENT OF THE VARIOUS MEDICAL CONDITIONS ASSOCIATED WITH POSTMENOPAUSAL SYNDROME | ELI LILLY AND COMPANY | 2001-09-18 | — | — | US | disclosed |
| EP-0902025-A2 | Benzothiophenes for treatment of estrogen related conditions | ELI LILLY AND COMPANY (US) | 1999-03-17 | — | — | EP | disclosed |