Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 14/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 12/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 11/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | CCRL2 | O00421 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7967885 | 1.00 | ADRA1A (0.51) | ADRA1AADRA1BADRA1DHRH1USP30 | |
| SCHEMBL7964225 | 0.90 | ADRA1A (0.50) | ADRA1AADRA1BADRA1DHRH1USP30 | |
| Hydrochloric Acid SCHEMBL7955646 | 0.89 | ADRA1A (0.49) | ADRA1AADRA1BADRA1DHRH1USP30 | |
| SCHEMBL7955794 | 0.85 | ADRA1A (0.52) | ADRA1AADRA1BADRA1DHRH1 | |
| SCHEMBL7955792 | 0.85 | ADRA1A (0.52) | ADRA1AADRA1BADRA1DHRH1 | |
| SCHEMBL7968147 | 0.83 | ADRA1A (0.39) | ADRA1AADRA1BADRA1DHRH1 | |
| SCHEMBL8150536 | 0.83 | ADRA1A (0.39) | ADRA1AADRA1BADRA1DHRH1 | |
| SCHEMBL7971326 | 0.82 | ADRA1A (0.51) | ADRA1AADRA1BADRA1DUSP30CCRL2 | |
| SCHEMBL7970730 | 0.82 | ADRA1A (0.51) | ADRA1AADRA1BADRA1DUSP30CCRL2 | |
| SCHEMBL6964799 | 0.82 | ADRA1A (0.51) | ADRA1AADRA1BADRA1DUSP30CCRL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6037354-A | ADMINISTERING PHENYL-SUBSTITUTED THIAZOLIDIN-4-ONE OR OXAZOLIDIN-2-ONE DERIVATIVE TO TREAT BENIGN PROSTATE HYPERPLASIA; SIDE EFFECT REDUCTION | MERCK & CO., INC. (US) | 2000-03-14 | — | — | US | claimed |
| US-6255315-B1 | BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC. | 2001-07-03 | — | — | US | disclosed |
| US-6037354-A | ADMINISTERING PHENYL-SUBSTITUTED THIAZOLIDIN-4-ONE OR OXAZOLIDIN-2-ONE DERIVATIVE TO TREAT BENIGN PROSTATE HYPERPLASIA; SIDE EFFECT REDUCTION | MERCK & CO., INC. (US) | 2000-03-14 | — | — | US | disclosed |