Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.50 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | HSD17B3 | P37058 | 6/20 | 0.47 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.41 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7044950 | 0.87 | HPGD (0.49) | HTTMAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL10794438 | 0.84 | HTT (0.61) | HTTPLA2G2APLA2G5MAPTFFAR1 | |
| SCHEMBL9806444 | 0.84 | HTT (0.61) | HTTPLA2G2APLA2G5MAPTFFAR1 | |
| SCHEMBL9806374 | 0.84 | HTT (0.61) | HTTPLA2G2APLA2G5MAPTFFAR1 | |
| SCHEMBL8823487 | 0.84 | HTT (0.61) | HTTPLA2G2APLA2G5MAPTFFAR1 | |
| SCHEMBL10350952 | 0.84 | HTT (0.61) | HTTPLA2G2APLA2G5MAPTFFAR1 | |
| SCHEMBL10351740 | 0.84 | HTT (0.61) | HTTPLA2G2APLA2G5MAPTFFAR1 | |
| SCHEMBL3277095 | 0.84 | HTT (0.61) | HTTPLA2G2APLA2G5MAPTFFAR1 | |
| SCHEMBL8142713 | 0.84 | HTT (0.61) | HTTPLA2G2APLA2G5MAPTFFAR1 | |
| SCHEMBL3650265 | 0.82 | HTT (0.63) | HTTPLA2G2APLA2G5MAPTFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6251928-B1 | ADMINISTERING BENZYLIDENE RHODANINES WHICH ARE USEFUL AS AGENTS IN TREATING OR PREVENTING CONDITIONS ASSOCIATED WITH BETA-AMYLOID PEPTIDE IN A MAMMAL | ELI LILLY AND COMPANY | 2001-06-26 | — | — | US | disclosed |
| US-5747517-A | ALZHEIMER'S DISEASE; PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 1998-05-05 | — | — | US | disclosed |
| EP-0677517-A1 | Treatment of Alzheimer's disease employing inhibitors of cathepsin D | ELI LILLY AND COMPANY (US) | 1995-10-18 | — | — | EP | disclosed |