Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.58 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | CMA1 | P23946 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14960824 | 1.00 | MAOB (0.58) | MAOBHCAR2RAB9AALOX5MAPK1 | |
| SCHEMBL12067561 | 0.87 | RAB9A (0.61) | MAOBHCAR2RAB9AALOX5MAPK1 | |
| SCHEMBL2853621 | 0.87 | RAB9A (0.61) | MAOBHCAR2RAB9AALOX5MAPK1 | |
| SCHEMBL2975996 | 0.87 | RAB9A (0.61) | MAOBHCAR2RAB9AALOX5MAPK1 | |
| SCHEMBL4906894 | 0.87 | HCAR2 (0.56) | HCAR2RAB9AALOX5MAPK1LMNA | |
| SCHEMBL4906886 | 0.87 | HCAR2 (0.56) | HCAR2RAB9AALOX5MAPK1LMNA | |
| SCHEMBL19076192 | 0.78 | APP (0.61) | RAB9AMAPK1MEN1MAPTKMT2A | |
| SCHEMBL22733864 | 0.78 | RAB9A (0.66) | HCAR2RAB9AALOX5MEN1MAPT | |
| SCHEMBL3933714 | 0.78 | RAB9A (0.66) | HCAR2RAB9AALOX5MEN1MAPT | |
| Diphenylamine SCHEMBL10426392 | 0.77 | RAB9A (0.51) | HCAR2RAB9AALOX5MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271383-B1 | USEFUL ACTIVITY AGAINST GRAM-POSITIVE PATHOGENS; IN PARTICULAR, AGAINST VARIOUS STRAINS EXHIBITING RESISTANCE TO VANCOMYCIN AND AGAINST E. FAECIUM STRAINS RESISTANT TO BOTH AMINOGLYCOSIDES AND CLINICALLY USED BETA-LACTAMS. | ZENECA LIMITED (GB) | 2001-08-07 | — | — | US | disclosed |